论文编号:ZY020论文字数:7266,页数:18
摘 要：本论文主要研究以对苯二酚为原料，经烷基化、溴代、格氏反应并成环合成苯并四氢双呋喃。苯并四氢双呋喃是一种重要的有机中间体，以苯并四氢双呋喃与D-或L-丙氨酸反应，羰基还原形成的中间产物可以合成一系列的衍生产物，这些衍生物对于5-羟色胺受体具有很高的亲和力，具有药用研究价值。苯并四氢双呋喃的合成收率40%，苯并四氢双呋喃跟丙氨酸反应合成衍生物的反应收率为66%。
关键词：合成;5-羟色胺;苯并四氢双呋喃;衍生物
article relates to the synthesis of tetrahydrobenzo[1,2-b:4,5-b]difuran which is an important organic intermediate. Beginning with hydroquinone,through alkylation, bromination and cyclization with Grignard reaction, the heterocyclic nucleus of tetrahydro-benzo[1,2-b;4,5-b]difuran is builded. Then the tetrahydrobenzo- [1,2-b:4,5-b]difuran reacts with D-or L-alanine, followed by ketone reduction, to produce an important organic intermediate. With this intermediate, then a series of derivatives can be prepared. These derivatives often have highe affinity acting on 5-HT Receptor, so have pharmaceutically- researched value. In the present experiments, tetrahydrobenzo-[1,2-b:4.5b]difuran is prepared in total yield of 40% and the tetrahydrobenzo-[1,2-b:45b]difuran reacts with alanine to produce derivatives in a yield of 66%.
Keywords: synthesis; 5-hydroxytryptamine; tetrahydrobenzo-[1,2-b: 4, 5-b]difuran; derivatives
目 录
中文摘要II
英文摘要II
目录III
1.绪论2
1.1 选题的背景2
1.2 选题的目的与意义2
2.实验部分2
2.1 实验仪器与试剂2
2.2实验操作步骤2
3.结果与讨论2
3.1 苯并四氢双呋喃的合成实验结果2
3.2苯并四氢双呋喃衍生物的合成2
4.总结与展望12
致 谢14
参考文献15
5-羟色胺受体激动剂合成与研究......